Article
Clues to the function of the tumour susceptibility gene BRCA2.
Disease markers - 1 Jun 1998
Gayther S A, Ponder B A
Abstract excerpt
The breast cancer susceptibility gene BRCA2 was isolated in 1995. BRCA2 is a large gene comprising 10,254 nucleotides and 26 coding exons. Neither the nucleotide nor the predicted protein sequences (comprising 3,418 amino acids) have provided substantial clues about its function. As a result, res...
Topics
- Animals
- BRCA2 Protein
- Breast Neoplasms
- Cell Division
- DNA Damage
- Female
- Genes, Tumor Suppressor
- Genetic Markers
- Genotype
- Humans
- Mice
- Neoplasm Proteins
- Phenotype
- Transcription Factors