Article
Clues to the function of the tumour susceptibility gene BRCA2.
Disease markers - 1 Jun 1998
Gayther S A, Ponder B A
Abstract excerpt
The breast cancer susceptibility gene BRCA2 was isolated in 1995. BRCA2 is a large gene comprising 10,254 nucleotides and 26 coding exons. Neither the nucleotide nor the predicted protein sequences (comprising 3,418 amino acids) have provided substantial clues about its function. As a result, researchers have been trying to elucidate the function using a combination of cell biological and biochemical methods and...
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