Article
Differential host susceptibility to pulmonary infections with bacteria and fungi in mice deficient in myeloperoxidase.
The Journal of infectious diseases - 1 Oct 2000
Aratani Y, Kura F, Watanabe H, Akagawa H, Takano Y, Suzuki K, Maeda N, Koyama H
Abstract excerpt
Myeloperoxidase (MPO), which is located within neutrophils capable of producing hypochlorous acid, is active in vitro against bacteria and fungi. However, MPO-deficient persons are usually healthy. To define the in vivo contribution of MPO to early host defense against pulmonary infections, MPO-deficient and control mice were intranasally infected with various fungi and bacteria, and the number of residual...
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