Article
Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate immunity.
Blood - 20 Jan 2011
Metzler Kathleen D, Fuchs Tobias A, Nauseef William M, Reumaux Dominique, Roesler Joachim, Schulze Ilka, Wahn Volker, Papayannopoulos Venizelos, Zychlinsky Arturo
Abstract excerpt
The granule enzyme myeloperoxidase (MPO) plays an important role in neutrophil antimicrobial responses. However, the severity of immunodeficiency in patients carrying mutations in MPO is variable. Serious microbial infections, especially with Candida species, have been observed in a subset of completely MPO-deficient patients. Here we show that neutrophils from donors who are completely deficient in MPO fail to...
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