Severe Impairment in Early Host Defense against<i>Candida albicans</i>in Mice Deficient in Myeloperoxidase

Abstract excerpt

Myeloperoxidase (MPO) catalyzes the reaction of hydrogen peroxide with chloride ion to produce hypochlorous acid (HOCl), which is used for microbial killing by phagocytic cells. Despite the important role of MPO in host defense, however, MPO deficiency is relatively common in humans, and most of these individuals are in good health. To define the in vivo role of MPO, we have generated by gene targeting mice...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neuroinflammation and Neurodegeneration Mechanisms
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
• Share to Nitric Oxide and Endothelin Effects