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Article

Myeloperoxidase-deficient zebrafish show an augmented inflammatory response to challenge with Candida albicans.

Fish & shellfish immunology - 1 May 2015

Wang Kun, Fang Xiao, Ma Ning, Lin Qing, Huang Zhibin, Liu Wei, Xu Mengchang, Chen Xiaohui, Zhang Wenqing, Zhang Yiyue

Abstract excerpt

Myeloperoxidase is a key component of neutrophil granules involved in killing engulfed microorganisms. We obtained a zebrafish mutant (smu681) lacking Sudan black staining by large-scale screening, which was a neutrophil-replete but myeloperoxidase-deficient mutant. When infiltrated with Candida albicans, smu681 embryos and sibling embryos showed similar survival after infection. Proliferation of C. albicans was...

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PMID: 25665803
DOI: 10.1016/j.fsi.2015.01.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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