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Article

The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling.

Development (Cambridge, England) - 1 Jun 2004

Sekimizu Kohshin, Nishioka Noriyuki, Sasaki Hiroshi, Takeda Hiroyuki, Karlstrom Rolf O, Kawakami Atsushi

Abstract excerpt

Members of the Hedgehog (Hh) family of intercellular signaling molecules play crucial roles in animal development. Aberrant regulation of Hh signaling in humans causes developmental defects, and leads to various genetic disorders and cancers. We have characterized a novel regulator of Hh signaling through the analysis of the zebrafish midline mutant iguana (igu). Mutations in igu lead to reduced expression of Hh...

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PMID: 15115751
DOI: 10.1242/dev.01059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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