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Article

Allele-specific gene targeting in Candida albicans results from heterology between alleles.

Microbiology (Reading, England) - 1 Sept 2000

Yesland Kyle, Fonzi William A

Abstract excerpt

The opportunistic fungal pathogen Candida albicans is asexual and diploid. Thus, introduction of recessive mutations requires targeted gene replacement of two alleles to effect expression of a recessive phenotype. This is often performed by recycling of a URA3 marker gene that is flanked by direct repeats of hisG. After targeting to a locus, recombination between the repeats excises URA3 leaving a single copy of...

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PMID: 10974097
DOI: 10.1099/00221287-146-9-2097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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