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New Clox Systems for Rapid and Efficient Gene Disruption in Candida albicans

18 Jun 2014

Abstract excerpt

Precise genome modification is essential for the molecular dissection of Candida albicans, and is yielding invaluable information about the roles of specific gene functions in this major fungal pathogen of humans. C. albicans is naturally diploid, unable to undergo meiosis, and utilizes a non-canonical genetic code. Hence, specialized tools have had to be developed for gene disruption in C. albicans that permit...

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PMID: 24940603
DOI: 10.1371/journal.pone.0100390

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