Article
New insights into the role of the complement pathway in allergy and asthma.
Current allergy and asthma reports - 1 Sept 2005
Wills-Karp Marsha, Koehl Joerg
Abstract excerpt
Despite extensive inquiry, the mechanisms underlying the pathophysiology of allergic diseases remain unknown. Recently, there has been a resurgence of interest in the role of the innate immune mediators of the complement pathway in asthma pathogenesis, particularly the anaphylatoxins (C3a, C5a). The emerging paradigm is that C3a production at the airway surface serves as a common pathway for the induction of...
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