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Article

Transcript Signatures in Experimental Asthma: Identification of STAT6-Dependent and -Independent Pathways

1 Feb 2004

Abstract excerpt

The analysis of polygenic diseases such as asthma poses a challenging problem. In an effort to provide unbiased insight into disease pathogenesis, we took an empirical approach involving transcript expression profiling of lung tissue from mice with experimental asthma. Asthmatic responses were found to involve sequential induction of 4.7% of the tested genome; notably, there was ectopic expression of a series of...

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PMID: 14734765
DOI: 10.4049/jimmunol.172.3.1815

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