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Article

Allergens induce enhanced bronchoconstriction and leukotriene production in C5 deficient mice.

Respiratory research - 17 Oct 2006

McKinley Laura, Kim Jiyoun, Bolgos Gerald L, Siddiqui Javed, Remick Daniel G

Abstract excerpt

BACKGROUND: Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production. We investigated the role of complement in a murine model of asthma-like pulmonary inflammation. METHODS: In order to evaluate the role of complement B10 mice either sufficient or...

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Identifiers

PMID: 17044927
DOI: 10.1186/1465-9921-7-129
PMCID: PMC1635702

Genes

AHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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