Article
Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.
PloS one - 1 Jan 2011
Santos José L, De la Cruz Rolando, Holst Claus, Grau Katrine, Naranjo Carolina, Maiz Alberto, Astrup Arne, Saris Wim H M, MacDonald Ian, Oppert Jean-Michel, Hansen Torben, Pedersen Oluf, Sorensen Thorkild I A, Martinez J Alfredo
Abstract excerpt
INTRODUCTION: The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat...
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