MC3R links nutritional state to childhood growth and the timing of puberty.

doi:10.1038/s41586-021-04088-9

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Article

MC3R links nutritional state to childhood growth and the timing of puberty.

Nature - 1 Nov 2021

Lam B Y H, Williamson A, Finer S, Day F R, Tadross J A, Gonçalves Soares A, Wade K, Sweeney P, Bedenbaugh M N, Porter D T, Melvin A, Ellacott K L J, Lippert R N, Buller S, Rosmaninho-Salgado J, Dowsett G K C, Ridley K E, Xu Z, Cimino I, Rimmington D, Rainbow K, Duckett K, Holmqvist S, Khan A, Dai X, Bochukova E G, Trembath R C, Martin H C, Coll A P, Rowitch D H, Wareham N J, van Heel D A, Timpson N, Simerly R B, Ong K K, Cone R D, Langenberg C, Perry J R B, Yeo G S, O'Rahilly S

Abstract excerpt

The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4 receptor (MC4R) to control appetite, food intake and energy expenditure2. Here we present evidence that MC3R regulates the timing of sexual maturation, the rate of linear growth and the...

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Identifiers

PMID: 34732894
DOI: 10.1038/s41586-021-04088-9
PMCID: PMC8819628

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