Article
The thrombomodulin gene mutation G(127)-->A (Ala25Thr) and cerebrovascular disease.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2000
Warner D, Catto A, Kunz G, Ireland H, Grant P J, Lane D A
Abstract excerpt
BACKGROUND AND PURPOSE: Thrombomodulin is an integral part of the protein C anticoagulation pathway, and polymorphisms of its gene have been implicated in thrombosis. The point mutation G(127)-->A has recently been found to be associated with myocardial infarction. METHODS: We investigated this mutation in 465 patients with acute stroke and 353 control subjects. Genomic DNA containing the region of interest was...
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