Article
Protein C deficiency found in a patient with acute myocardial infarction: a single base mutation 157 Arg (CGA) to stop codon (TGA).
International journal of hematology - 1 Dec 1994
Nakagawa K, Tsuji H, Masuda H, Kitamura H, Nakahara Y, Ogasahara Y, Okajima Y, Sawada S, Nakagawa M
Abstract excerpt
Protein C has an important role in the regulatory mechanisms of coagulation and fibrinolysis. In patients with heterozygous protein C deficiency, there is an increased risk for thromboembolic disease, especially in the venous system. We describe a patient with protein C deficiency presenting with an acute myocardial infarction (AMI). Direct sequence analysis of the whole protein C gene detected a single base...
Topics
- Base Sequence
- Codon
- Exons
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Myocardial Infarction
- Protein C
- Protein C Deficiency