Article
A mutation in the thrombomodulin gene, 127G to A coding for Ala25Thr, and the risk of myocardial infarction in men.
Thrombosis and haemostasis - 1 Nov 1998
Doggen C J, Kunz G, Rosendaal F R, Lane D A, Vos H L, Stubbs P J, Manger Cats V, Ireland H
Abstract excerpt
Thrombomodulin is an endothelial cell surface receptor that transforms the procoagulant thrombin into an anticoagulant. A mutation in the thrombomodulin gene is a potential risk factor for venous and arterial thrombosis. We screened a region within the coding sequence of the thrombomodulin gene b...
Topics
- Age Factors
- Amino Acid Substitution
- Case-Control Studies
- Codon
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Myocardial Infarction
- Netherlands
- Pilot Projects
- Point Mutation
- Polymorphism, Single-Stranded Conformational
- Risk
- Risk Factors
- Smoking
- Thrombomodulin
- Thrombophilia