Article
Genetic variation in the human thrombomodulin promoter locus and prognosis after acute coronary syndrome.
Thrombosis research - 1 Jan 2004
Ohlin Ann-Kristin, Holm Johan, Hillarp Andreas
Abstract excerpt
INTRODUCTION: Endothelial thrombomodulin (TM) plays a critical role in both anticoagulation and anti-inflammation. An impaired TM cofactor function or reduced TM gene expression could constitute a prethrombotic abnormality leading to acute coronary events. Mutations in the TM gene occur, but their functional consequences on the expression and activity of the gene are not yet fully understood. MATERIALS AND...
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