The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease.

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Article

The first mutation identified in the thrombomodulin gene in a 45-year-old man presenting with thromboembolic disease.

Blood - 15 Jan 1995

Ohlin A K, Marlar R A

Abstract excerpt

Thrombomodulin (TM) is the anticoagulant endothelial cell membrane-bound protein cofactor in the thrombin-mediated activation of protein C (PC). It has been clearly demonstrated that the anticoagulant and profibrinolytic functions of the PC system are important for the prevention of a thromboembo...

Topics

Adult
Alleles
Base Sequence
DNA Mutational Analysis
Female
Gene Frequency
Humans
Male
Middle Aged
Molecular Sequence Data
Point Mutation
Polymorphism, Restriction Fragment Length
Polymorphism, Single-Stranded Conformational
Pulmonary Embolism
Thrombomodulin

Source

Open in PubMed

Identifiers

PMID: 7811989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7811989-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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