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Article

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells.

The EMBO journal - 1 Sept 2000

Gillooly D J, Morrow I C, Lindsay M, Gould R, Bryant N J, Gaullier J M, Parton R G, Stenmark H

Abstract excerpt

Phosphatidylinositol 3-kinase (PI3K) regulates several vital cellular processes, including signal transduction and membrane trafficking. In order to study the intracellular localization of the PI3K product, phosphatidylinositol 3-phosphate [PI(3)P], we constructed a probe consisting of two PI(3)P-binding FYVE domains. The probe was found to bind specifically, and with high affinity, to PI(3)P both in vitro and in...

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Identifiers

PMID: 10970851
DOI: 10.1093/emboj/19.17.4577
PMCID: PMC302054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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