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Article

Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.

Biochimica et biophysica acta - 1 May 2015

Ikonomov Ognian C, Sbrissa Diego, Venkatareddy Madhusudan, Tisdale Ellen, Garg Puneet, Shisheva Assia

Abstract excerpt

The evolutionarily conserved PIKfyve, which synthesizes PtdIns5P from PtdIns, and PtdIns(3,5)P2 from PtdIns3P, requires PtdIns3P as both an enzyme substrate and a membrane recruitment signal. Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of the eight mammalian PI3Ks, is presumed as a main candidate. A hallmark of PIKfyve deficiency is formation of multiple...

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Identifiers

PMID: 25619930
DOI: 10.1016/j.bbamcr.2015.01.008
PMCID: PMC4431544

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