Article
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
The Journal of biological chemistry - 3 Oct 2003
Whitley Paul, Reaves Barbara J, Hashimoto Makoto, Riley Andrew M, Potter Barry V L, Holman Geoffrey D
Abstract excerpt
Phosphatidylinositol 3,5-bisphosphate is a membrane lipid found in all eukaryotes so far studied but downstream effector proteins of this lipid have yet to be identified. Here we report the use of cDNA phage libraries in conjunction with synthetic biotinylated derivatives of phosphatidylinositol 3,5-bisphosphate in the identification of a mammalian phosphatidylinositol 3,5-bisphosphate-binding protein, mVps24p....
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