Article
Promoter variants of the human mannose-binding lectin gene show different binding.
Biochemical and biophysical research communications - 28 Aug 2000
Jüliger S, Luckner D, Mordmüller B, May J, Weierich A, Lell B, Luty A, Kremsner P G, Kun J F
Abstract excerpt
Mannose-binding lectin (MBL) levels in the plasma of humans are highly variable. The level is influenced by gene mutations in exon1 and the promoter. Here we describe the distribution of three point mutations linked with a deletion in the MBL gene promoter in populations of Central Africa, Thailand, and Papua New Guinea. Among African children we find 20% with the wild-type allele, 53% are heterozygous, and 27%...
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