Article
Association of mannose-binding lectin 2 gene polymorphic variants with susceptibility and clinical progression in systemic lupus erythematosus.
Clinical and experimental rheumatology - 1 Jan 2000
Glesse Nadine, Monticielo Odirlei A, Mattevi Vanessa S, Brenol Joao C T, Xavier Ricardo M, da Silva Gabriela K, Dos Santos Bruno P, Rucatti Guilherme G, Chies José A B
Abstract excerpt
OBJECTIVES: This study investigates the role of mannose-binding lectin (MBL) in susceptibility and clinical expression of systemic lupus erythematosus (SLE), through the analysis of promoter region and exon 1 polymorphisms of the MBL2 gene. METHODS: We analysed 325 SLE patients from the Hospital de Clínicas de Porto Alegre and 344 controls. All individuals were grouped according to ethnic origin. Genotyping of...
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