Article
Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1998
Madsen H O, Satz M L, Hogh B, Svejgaard A, Garred P
Abstract excerpt
Previous studies have shown that three point mutations in exon 1 and a particular promoter haplotype of the mannan-binding lectin (MBL) gene lead to a dramatic decrease in the serum concentration of MBL. In this study, MBL genotypes and serum concentrations were determined in unrelated individuals in a population from Mozambique (n = 154) and in two native Indian tribes from Argentina (i.e., the Chiriguanos (n =...
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