Article
Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 1998
Madsen H O, Satz M L, Hogh B, Svejgaard A, Garred P
Abstract excerpt
Previous studies have shown that three point mutations in exon 1 and a particular promoter haplotype of the mannan-binding lectin (MBL) gene lead to a dramatic decrease in the serum concentration of MBL. In this study, MBL genotypes and serum concentrations were determined in unrelated individual...
Topics
- Argentina
- Base Sequence
- Carrier Proteins
- Child
- Collectins
- Denmark
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Indians, South American
- Lectins
- Mannans
- Molecular Sequence Data
- Mozambique
- Prospective Studies
- Sequence Analysis, DNA
- White People