Article
Lack of activating c-SRC mutations at codon 531 in rectal cancer.
Cancer genetics and cytogenetics - 1 Aug 2000
Nilbert M, Fernebro E
Abstract excerpt
Cellular SRC (c-SRC), which is the human homolog of the Rous sarcoma viral oncogene, v-src, is highly activated in colorectal cancer. Recently, a subset of colon cancers have shown a nonsense mutation at codon 531, which truncates c-SRC directly C-terminal to the c-SRC kinase regulatory domain. This specific mutation has been demonstrated to be activating, transforming, and tumorigenic and to promote metastasis....
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