Article
c-src structure in human cancers with elevated pp60c-src activity.
British journal of cancer - 1 Sept 1991
Wang P, Fromowitz F, Koslow M, Hagag N, Johnson B, Viola M
Abstract excerpt
We used RNAase protection and restriction fragment length polymorphism assays to detect activating mutations of c-src in a spectrum of human tumours. No mutations were detected at codons 98, 381, 444, and 530. We conclude that mutational activation is not the mechanism of enhancement of pp60c-src-specific kinase activity found in a number of human cancer types.
Topics
- Base Sequence
- Codon
- Genes, src
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Neoplasms
- Oligodeoxyribonucleotides
- Polymorphism, Restriction Fragment Length
- Protein-Tyrosine Kinases