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Article

Beta-catenin activation through mutation is rare in rectal cancer.

Cancer genetics and cytogenetics - 1 Jul 2001

Nilbert M, Rambech E

Abstract excerpt

Increased transcriptional activation through beta-catenin stabilization plays a central role in colorectal tumorigenesis. Alterations of phosphorylation sites within the CTNNB1 gene, which codes for beta-catenin has been reported to occur in about one-half of colorectal tumors without APC-gene mutations. We assessed the importance of mutations in the regulatory domain, located within exon 3 of CTNNB1, in 103...

Read the complete abstract on PubMed

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Share to beta Catenin
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frameshift Mutation

Share to Genes, APC

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Share to Transcription Factor 7-Like 2 Protein

Source

Identifiers

PMID: 11454429
DOI: 10.1016/s0165-4608(01)00397-1

Genes

CTNNB1
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Beta-catenin activation through mutation is rare in rectal cancer.PMID 11454429Read ↗

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