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Article

Activating SRC mutation in a subset of advanced human colon cancers.

Nature genetics - 1 Feb 1999

Irby R B, Mao W, Coppola D, Kang J, Loubeau J M, Trudeau W, Karl R, Fujita D J, Jove R, Yeatman T J

Abstract excerpt

The discovery of Rous sarcoma virus (RSV) led to the identification of cellular Src (c-Src), a non-receptor tyrosine kinase, which has since been implicated in the development of numerous human cancers. c-Src has been found to be highly activated in colon cancers, particularly in those metastatic to the liver. Studies of the mechanism of c-Src regulation have suggested that c-Src kinase activity is downregulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9988270
DOI: 10.1038/5971

Genes

SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Activating SRC mutation in a subset of advanced human colon cancers.PMID 9988270Read ↗

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