Article
Absence of tyrosine kinase mutations in Japanese colorectal cancer patients.
Oncogene - 29 Mar 2007
Shao R-X, Kato N, Lin L-J, Muroyama R, Moriyama M, Ikenoue T, Watabe H, Otsuka M, Guleng B, Ohta M, Tanaka Y, Kondo S, Dharel N, Chang J-H, Yoshida H, Kawabe T, Omata M
Abstract excerpt
Tyrosine kinases, which are important regulators of intracellular signal-transduction pathways, have mutated forms that are often associated with oncogenesis and are attractive targets for therapeutic intervention. Recently, systematic mutational analyses of tyrosine kinases revealed that a minim...
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