Article
Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients.
British journal of cancer - 1 Jan 2001
Laghi L, Bianchi P, Orbetegli O, Gennari L, Roncalli M, Malesci A
Abstract excerpt
A truncating mutation (C to T transition) at codon 531 of the human protooncogene c-src, possibly accounting for the activation of c-src tyrosine kinase, has been recently identified in a subset of advanced colorectal cancer from North-American patients. However, two subsequent studies have failed to confirm the occurrence of SRC 531 mutation in colorectal cancers from North-European and Asiatic patients, raising...
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