No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese.

doi:10.1016/s0304-3835(99)00398-5

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Article

No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese.

Cancer letters - 31 Mar 2000

Wang N M, Yeh K T, Tsai C H, Chen S J, Chang J G

Abstract excerpt

The protein tyrosine kinase activity of c-src proto-oncogene product, pp60(c-src), is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60(c-src) carboxy-terminal tyrosine 530 suppresses its kinase activity. A recent report suggested that the risk of colon cancer is higher for those who carry a C-->T transition mutation on codon 531 (Gln-531-->Amber-531) of src gene. This...

Topics

China
Codon
Colonic Neoplasms
Genes, src
Humans
Mutation
Polymerase Chain Reaction
Proto-Oncogene Mas

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Open in PubMed

Identifiers

PMID: 10704743
DOI: 10.1016/s0304-3835(99)00398-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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