Article
Bypassing hybridoma technology: HLA-C reactive human single-chain antibody fragments (scFv) derived from a synthetic phage display library (HuCAL) and their potential to discriminate HLA class I specificities.
Tissue antigens - 1 Jul 2000
Marget M, Sharma B B, Tesar M, Kretzschmar T, Jenisch S, Westphal E, Davarnia P, Weiss E, Ulbrecht M, Kabelitz D, Krönke M
Abstract excerpt
The generation of discriminative, monospecific anti-HLA antibodies used to be a difficult endeavor. Phage display technology, using single-chain antibody fragments (scFv) offers a powerful alternative obtaining target-specific, genetically stable reagents. Most of scFv obtained to date have been enriched by panning phage libraries to solid-phase coupled antigens. In the present study, HLA-C-specific scFv were...
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