Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human anti-self antibodies with high specificity from phage display libraries.

The EMBO journal - 1 Feb 1993

Griffiths A D, Malmqvist M, Marks J D, Bye J M, Embleton M J, McCafferty J, Baier M, Holliger K P, Gorick B D, Hughes-Jones N C

Abstract excerpt

Recently we demonstrated that human antibody fragments with binding activities against foreign antigens can be isolated from repertoires of rearranged V-genes derived from the mRNA of peripheral blood lymphocytes (PBLs) from unimmunized humans. The heavy and light chain V-genes were shuffled at random and cloned for display as single-chain Fv (scFv) fragments on the surface of filamentous phage, and the fragments...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Antibody Specificity

Share to Autoantibodies

Share to Epitopes

Share to Immunoglobulin Variable Region

Share to Molecular Sequence Data

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 7679990
DOI: 10.1002/j.1460-2075.1993.tb05706.x
PMCID: PMC413258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human anti-self antibodies with high specificity from phage display libraries.PMID 7679990Read ↗

A compact phage display human scFv library for selection of antibodies to a wide variety of antigensSemantic proximity Read ↗

Isolation of high-affinity monomeric human anti-c-erbB-2 single chain Fv using affinity-driven selection.Semantic proximity Read ↗

Rapid selection of cell subpopulation-specific human monoclonal antibodies from a synthetic phage antibody library.Semantic proximity Read ↗

Generation, Diversity Determination, and Application to Antibody Selection of a Human Naïve Fab LibrarySemantic proximity Read ↗

Discovery of diverse and functional antibodies from large human repertoire antibody librariesSemantic proximity Read ↗

A Highly Functional Synthetic Phage Display Library Containing over 40 Billion Human Antibody ClonesSemantic proximity Read ↗

Selection and Application of Human Single Chain Fv Antibody Fragments from a Semi-synthetic Phage Antibody Display Library with Designed CDR3 RegionsSemantic proximity Read ↗

Guiding the Selection of Human Antibodies from Phage Display Repertoires to a Single Epitope of an AntigenSemantic proximity Read ↗

By-passing immunization. Human antibodies from V-gene libraries displayed on phage.Semantic proximity Read ↗

Phage Display for the Generation of Antibodies for Proteome Research, Diagnostics and TherapySemantic proximity Read ↗

Human Antibody Fragments Specific for Human Blood Group Antigens from a Phage Display LibrarySemantic proximity Read ↗

Selection of a PD ‐1 blocking antibody from a novel fully human phage display librarySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.