Article
Human anti-self antibodies with high specificity from phage display libraries.
The EMBO journal - 1 Feb 1993
Griffiths A D, Malmqvist M, Marks J D, Bye J M, Embleton M J, McCafferty J, Baier M, Holliger K P, Gorick B D, Hughes-Jones N C
Abstract excerpt
Recently we demonstrated that human antibody fragments with binding activities against foreign antigens can be isolated from repertoires of rearranged V-genes derived from the mRNA of peripheral blood lymphocytes (PBLs) from unimmunized humans. The heavy and light chain V-genes were shuffled at r...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Specificity
- Autoantibodies
- Bacteriophages
- Epitopes
- Genomic Library
- Immunoglobulin Variable Region
- Molecular Sequence Data
- Mutation