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A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders

6 Apr 2012

Abstract excerpt

A synthetic human V(L) phage display library, created by the randomization of all complementarity-determining regions (CDRs) in a V(L) scaffold, was panned against three test antigens to determine the propensity of the library to yield non-aggregating binders. A total of 22 binders were isolated against the test antigens and the majority (20) were monomeric. Thus, human V(L) repertoires provide an efficient...

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PMID: 22490957
DOI: 10.1093/protein/gzs014

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