A Highly Functional Synthetic Phage Display Library Containing over 40 Billion Human Antibody Clones

Abstract excerpt

Several synthetic antibody phage display libraries have been created and used for the isolation of human monoclonal antibodies. The performance of antibody libraries, which is usually measured in terms of their ability to yield high-affinity binding specificities against target proteins of interest, depends both on technical aspects (such as library size and quality of cloning) and on design features (which...

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