Article

Rapid dexamethasone treatment inhibits LPS-induced cytokine storm in mice

2023-12-07

Abstract excerpt

Severe infection-induced cytokine storm is an urgent medical syndrome with high mortality. To date, no therapy is available. This study shows that high concentrations of lipopolysaccharide (LPS) induce cytokine storm within 48h and thus kill most experimental mice. Rapid, but not late dexamethasone administration remarkably inhibits cytokine storm and rescues LPS-treated mice. Monocytes and macrophages are the maj...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7a90705f-61a3-54c2-8a55-2c5dada1da01
DOI: 10.1101/2023.12.07.570372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapid dexamethasone treatment inhibits LPS-induced cytokine storm in miceDOI 10.1101/2023.12.07.570372Read

The glucocorticoid dexamethasone impairs the expression of anti-viral mediators in activated macrophages by inhibiting both expression and function of interferon βSemantic proximity Read

Cytokine storm and sepsis disease pathogenesis.Semantic proximity Read

A primer on cytokines: sources, receptors, effects, and inducers.Semantic proximity Read

Interleukin-17A released from intestinal γδT cells induces cytokine storm in mice with severe dengueSemantic proximity Read

Systemic inflammation impairs human myelopoiesis and interferon I responsesSemantic proximity Read

The Role of Glucocorticoids in Inflammatory Diseases.Semantic proximity Read

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathwaySemantic proximity Read

Inhibition of the TLR4/NF-κB/TNF-α axis by TAK-242 or PDTC reduces central nervous system inflammation to alleviate lipopolysaccharide induced sickness behaviors in miceSemantic proximity Read

Inhibition of IL-1, IL-6, and TNF-α in immune-mediated inflammatory diseasesSemantic proximity Read

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock SyndromesSemantic proximity Read

Bacterial Perturbation of Cytokine NetworksSemantic proximity Read

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.Semantic proximity Read