Endogenous Uteroglobin as Intrinsic Anti-inflammatory Signal Modulates Monocyte and Macrophage Subsets Distribution Upon Sepsis Induced Lung Injury

Abstract excerpt

Sepsis is a serious clinical condition with life-threatening organ dysfunction, and limited therapeutic options. The paradigm of limiting excessive inflammation and promoting anti-inflammatory responses is a simplified concept. Yet, the absence of intrinsic anti-inflammatory signalling at the early stage of an infection can lead to exaggerated activation of immune cells including monocytes and macrophages. There...