Article
Hot microscopic areas of iodine-deficient euthyroid goitres contain constitutively activating TSH receptor mutations.
The Journal of pathology - 1 Sept 2000
Krohn K, Wohlgemuth S, Gerber H, Paschke R
Abstract excerpt
Constitutively activating TSH receptor mutations have been established as the most common molecular basis for the pathogenesis of toxic thyroid nodules. These mutations result in uncontrolled signalling through the TSH receptor that is likely to cause hyperfunction and proliferation. The incidence of toxic multinodular goitres has been demonstrated to be related to iodine deficiency. Moreover, scintigraphically...
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