Article
Activating thyrotropin receptor mutations in histologically heterogeneous hyperfunctioning nodules of multinodular goiter.
Thyroid : official journal of the American Thyroid Association - 1 Jul 1998
Tonacchera M, Vitti P, Agretti P, Giulianetti B, Mazzi B, Cavaliere R, Ceccarini G, Fiore E, Viacava P, Naccarato A, Pinchera A, Chiovato L
Abstract excerpt
Activating thyrotropin (TSH) receptor mutations have been found in toxic adenomas and in hot nodules contained in toxic multinodular goiter. The typical feature of multinodular goiter is the heterogeneity in morphology and function of different follicles within the same enlarged gland. In this re...
Topics
- Cyclic AMP
- GTP-Binding Protein alpha Subunits, Gs
- Goiter, Nodular
- Humans
- Male
- Middle Aged
- Mutation
- Receptors, Thyrotropin
- Thyroxine
- Triiodothyronine