Activating Thyrotropin Receptor Mutations Are Present in Nonadenomatous Hyperfunctioning Nodules of Toxic or Autonomous Multinodular Goiter*

Abstract excerpt

Toxic multinodular goiter, a heterogeneous disease producing hyperthyroidism, is frequently found in iodine-deficient areas. The pathogenesis of this common clinical entity is still unclear. The aim of the present study was to search for activating TSH receptor (TSHr) or Gs alpha mutations in areas of toxic or functionally autonomous multinodular goiters that appeared hyperfunctioning at thyroid scintiscan but...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Ion channel regulation and function
• Share to Thyroid Cancer Diagnosis and Treatment
• Share to Thyroid Disorders and Treatments