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Growth of rotaviruses in continuous human and monkey cell lines that vary in their expression of integrins

1 Sept 2000

Abstract excerpt

Rotavirus replication occurs in vivo in intestinal epithelial cells. Cell lines fully permissive to rotavirus include kidney epithelial (MA104), colonic (Caco-2) and hepatic (HepG2) types. Previously, it has been shown that cellular integrins alpha 2 beta 1, alpha 4 beta 1 and alpha X beta 2 are involved in rotavirus cell entry. As receptor usage is a major determinant of virus tropism, the levels of cell surface...

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PMID: 10950978
DOI: 10.1099/0022-1317-81-9-2203

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