Poliovirus mutants resistant to neutralization with soluble cell receptors.

doi:10.1126/science.2177226

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Article

Poliovirus mutants resistant to neutralization with soluble cell receptors.

Science (New York, N.Y.) - 14 Dec 1990

Kaplan G, Peters D, Racaniello V R

Abstract excerpt

Poliovirus mutants resistant to neutralization with soluble cellular receptor were isolated. Replication of soluble receptor-resistant (srr) mutants was blocked by a monoclonal antibody directed against the HeLa cell receptor for poliovirus, indicating that the mutants use this receptor to enter cells. The srr mutants showed reduced binding to HeLa cells and cell membranes. However, the reduced binding phenotype...

Topics

Animals
Antibodies, Monoclonal
Antiviral Agents
Baculoviridae
Cell Line
Cell Membrane
Centrifugation, Density Gradient
DNA
Genetic Vectors
HeLa Cells
Humans
Insecta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Poliovirus

Receptors, Virus

Recombinant Proteins

Transfection

Source

Open in PubMed

Identifiers

PMID: 2177226
DOI: 10.1126/science.2177226

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2177226-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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