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Article

Cholangiocyte expression of α<sub>2</sub>β<sub>1</sub>-integrin confers susceptibility to rotavirus-induced experimental biliary atresia

25 Apr 2008

Abstract excerpt

Inoculation of BALB/c mice with rhesus rotavirus (RRV) in the newborn period results in biliary epithelial cell (cholangiocyte) infection and the murine model of biliary atresia. Rotavirus infection of a cell requires attachment, which is governed in part by cell-surface expression of integrins such as alpha2beta1. We hypothesized that cholangiocytes were susceptible to RRV infection because they express...

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PMID: 18436621
DOI: 10.1152/ajpgi.00442.2007

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