Article
Foot-and-mouth disease virus virulent for cattle utilizes the integrin alpha(v)beta3 as its receptor.
Journal of virology - 1 May 1998
Neff S, Sá-Carvalho D, Rieder E, Mason P W, Blystone S D, Brown E J, Baxt B
Abstract excerpt
Adsorption and plaque formation of foot-and-mouth disease virus (FMDV) serotype A12 are inhibited by antibodies to the integrin alpha(v)beta3 (A. Berinstein et al., J. Virol. 69:2664-2666, 1995). A human cell line, K562, which does not normally express alpha(v)beta3 cannot replicate this serotype unless cells are transfected with cDNAs encoding this integrin (K562-alpha(v)beta3 cells). In contrast, we found that...
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