Article
p53 protein overexpression and gene mutation in mixed Müllerian tumors of the uterus.
Cancer detection and prevention - 1 Jan 1999
Soong R, Knowles S, Hammond I G, Michael C, Iacopetta B J
Abstract excerpt
Alteration of the p53 tumor suppressor gene is associated with poor prognosis in many human cancer types. We examined the incidence and prognostic significance of p53 gene alterations in a series of uterine malignant mixed Müllerian tumors (MMT). Nuclear overexpression of p53 protein detected by...
Topics
- Adult
- DNA, Neoplasm
- Exons
- Female
- Follow-Up Studies
- Genes, p53
- Genetic Markers
- Humans
- Immunoenzyme Techniques
- Mixed Tumor, Mullerian
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prognosis
- Retrospective Studies
- Tumor Suppressor Protein p53
- Uterine Neoplasms