Article
Detection of tumor mutant APC DNA in plasma of patients with sporadic colorectal cancer.
In vivo (Athens, Greece) - 1 Jan 2000
Ling E, Fich A, Man S, Wolfson M, Mikhailowsky R, Lamprecht S A
Abstract excerpt
The aim of this study was to detect mutant APC DNA of tumor origin in the plasma of patients with sporadic colorectal carcinomas. The polymerase chain reaction (PCR) and the single strand conformation polymorphism (SSCP) procedures were employed to detect DNA alterations using primers to amplify the mutation cluster region of the APC gene. APC mutations were observed in 7 out of 11 archival colonic tumor...
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