Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.

Journal of the National Cancer Institute - 7 Jun 2000

Kopreski M S, Benko F A, Borys D J, Khan A, McGarrity T J, Gocke C D

Abstract excerpt

BACKGROUND: Many cancers are attributed to somatic mutation of DNA. We investigated whether it is feasible to detect cancer-associated somatic mutations in patients with neoplasms by using plasma DNA. METHODS: Plasma samples were prospectively collected from 240 patients undergoing colonoscopy. Colorectal biopsies were performed as clinically indicated in 135 patients, and risk factor information was available...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Gene Amplification

Share to Genes, ras

Share to Mutation

Share to Polymerase Chain Reaction

Share to Risk Factors

Source

Identifiers

PMID: 10841827
DOI: 10.1093/jnci/92.11.918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.PMID 10841827Read ↗

K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.Semantic proximity Read ↗

Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.Semantic proximity Read ↗

Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.Semantic proximity Read ↗

p53 and APC mutations are detectable in the plasma and serum of patients with colorectal cancer (CRC) or adenomas.Semantic proximity Read ↗

Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.Semantic proximity Read ↗

Tumor-associated DNA mutation detection in individuals undergoing colonoscopy.Semantic proximity Read ↗

Novel Clinical Tool to Estimate Risk of False-Negative KRAS Mutations in Circulating Tumor DNA Testing.Semantic proximity Read ↗

Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.Semantic proximity Read ↗

Cell-free circulating RAS mutation concentrations significantly impact the survival of metastatic colorectal cancer patients.Semantic proximity Read ↗

Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.Semantic proximity Read ↗

Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients.Semantic proximity Read ↗

Detection of tumour DNA in serum of colorectal cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.