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Article

Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.

Journal of the National Cancer Institute - 7 Jun 2000

Kopreski M S, Benko F A, Borys D J, Khan A, McGarrity T J, Gocke C D

Abstract excerpt

BACKGROUND: Many cancers are attributed to somatic mutation of DNA. We investigated whether it is feasible to detect cancer-associated somatic mutations in patients with neoplasms by using plasma DNA. METHODS: Plasma samples were prospectively collected from 240 patients undergoing colonoscopy. Colorectal biopsies were performed as clinically indicated in 135 patients, and risk factor information was available...

Topics

Adenoma
Carcinoma
Colonoscopy
Colorectal Neoplasms
DNA, Neoplasm
Feasibility Studies
Gene Amplification
Genes, ras
Humans
Mass Screening
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Prospective Studies

Risk Factors

Source

Identifiers

PMID: 10841827
DOI: 10.1093/jnci/92.11.918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10841827-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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