Article
Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue.
Cancer - 1 Sept 1998
Otori K, Konishi M, Sugiyama K, Hasebe T, Shimoda T, Kikuchi-Yanoshita R, Mukai K, Fukushima S, Miyaki M, Esumi H
Abstract excerpt
BACKGROUND: The authors examined somatic mutations of the adenomatous polyposis coli (APC) gene in 84 human aberrant crypt foci (ACF) to determine whether APC gene mutations were involved in the histologic progression of ACF. METHODS: Mutation cluster regions of the APC gene were subjected to pol...
Topics
- Adenomatous Polyposis Coli
- Aged
- Aged, 80 and over
- Colonic Neoplasms
- Gene Deletion
- Humans
- Intestinal Mucosa
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational