Article
Detection of APC mutations in stool DNA of patients with colorectal cancer by HD-PCR.
Human mutation - 1 Jan 1998
Deuter R, Müller O
Abstract excerpt
In most cases the analysis of DNA mutations in presence of a high excess of wild type DNA fail because of the low sensitivity of the performed method for mutation detection. Here we describe the new high-sensitive and non-radioactive HD-PCR method (for HeteroDuplex-PCR). In opposite to the conventional analytical application the heteroduplex technique is performed to preparatively separate mutated from...
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