Article
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
Lancet (London, England) - 12 Sept 1992
Cottrell S, Bicknell D, Kaklamanis L, Bodmer W F
Abstract excerpt
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers. By screening with single-strand conformation polymorphism analysis we identified several mutations in a small region of the APC gene in both FAP and sporadic c...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- Blotting, Southern
- Chromosome Deletion
- Colorectal Neoplasms
- DNA
- DNA Mutational Analysis
- DNA Transposable Elements
- Gene Frequency
- Genetic Counseling
- Genetic Testing
- Humans
- Molecular Sequence Data
- Mutation
- Pedigree
- Restriction Mapping