Article
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
Lancet (London, England) - 12 Sept 1992
Cottrell S, Bicknell D, Kaklamanis L, Bodmer W F
Abstract excerpt
Mutations in the APC gene give rise to familial adenomatous polyposis (FAP) and also occur in many, perhaps most, sporadic colon cancers. By screening with single-strand conformation polymorphism analysis we identified several mutations in a small region of the APC gene in both FAP and sporadic cancers. These mutations were either point mutations or small deletions or insertions causing frameshifts, and all...
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